Cooperation of idiotypic and anti-idiotypic antibodies at the steroid-depended chemical carcinogenesis

Immunological research of steroid-depended chemical carcinogenesis in humans is based on positive experience the clinical usage selective estrogen receptor modulators and experimental design immunological methods for human protection from environmental carcinogens. Our study aimed idiotypic antibodies against benzo[a]pyrene, estradiol progesterone (IgA1-Bp, IgA1-E2 IgA1-Pg), connection with anti-idiotypic specific to (IgG2-E2 IgG2-Pg) serum samples postmenopausal healthy women (HW) ER+/PR+ stage I breast cancer patients (BCP). Idiotypic were studied 402 HW 475 BCP using ELISA technique, BP, E2 Pg conjugated bovine albumin as adsorbed antigens. The method monoclonal High individual ratios IgA1-Bp/ IgA1-Pg 1 IgA1-E2/IgA1-Pg revealed 42.1% 48.5% HW, 71.1% 78.1% cases (p 0.0001, OR = 5.9 3.8, respectively). IgG2-E2 4 levels found 23.4% 41.2% group 2.3). Combination IgA1-Bp/IgA1-Pg IgG2-Pg 2 was more common than (29.3% vs 5.8%, p 0.1). Combinations 1with or frequent BCP, (12.0% 31.8% 4.9% 15.2%, accordingly, 0.01, 2.7 0.001, 2.6), well combination (23.4% 9.8%, 0.0003, 2.8). Similar features when studying ratio IgG2-Pg. Nevertheless, high combined low + (27.7% 28.8%) frequently, (19.7%, 0.06 17.9%, 0.008). Excess IgA1-Bp over associated BC condition may serve an marker preventive therapy by targeted ER modulators.